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About Research Publications Collaboration Home

Chao Zhang, Principal Investigator

PhD in Computer Science, MSc in Statistics
Assisstant Professor in Computational Biomedicine, Boston University School of Medicine

Research interests:

  • Time-series single-cell data analysis for aging marker detection
  • Sinlge cell ATAC and RNASeq data integration
  • Discovering the associations between microbiome and tumor immune microenvironment

Open Positions : Postdoctoral Associate in Bioinformatics

  • PhD in Computational Biology, Computer Science, Data Science, Bioinformatics, Biostatistics, Mathematics or other related quantitative areas.
  • To apply, please submit a Curriculum Vitae together with a Statement of Research Interests with the form. Review of applications will continue until the position is filled.

Microbiome

Microbiome identification from small clinical samples; Evaluating the host microenvironment - microbiome interactions in cancers.

Stem Cell

Using iPSC platform to study aging and neurodegeneration diseases; Understanding the function of lipid regulating stem cell fate.

Cancer

Evaluating the epigenetic evolution and seeking epigenetic cancer drivers; Discvoering the molecular mechanisms of tumour resistance to chemotherapy

Methodology

Developing novel machine learning methods for multi-omics data integration; Algorithms and applications implementations of network analysis.

You can visit Goolge Scholar or PubMed Bibliography for more detail


Selected publications:

# Co-first authors; * Co-corresponding authors
  • Pan H, Renaud L, Chaligne R, Bloehdorn J, Tausch E, Mertens D, Fink AM, Fischer K, Zhang C, Betel D, Gnirke A, Imielinski M, Moreaux J, Hallex M, Meissner A, Stilgenbauer S, Wu CJ, Elemento O, Landau DA. Discovery of candidate DNA methylation cancer driver genes. Cancer Discovery. 2021
    [Abstract] [Full Paper]
  • Galletti G, Zhang C, Gjyrezi A, Cleveland K, Zhang J, Powell S, Thakkar PV, Betel D, Shah MA, Giannakakou P. Microtubule engagement with taxane is altered in taxane-resistant gastric cancer. Clinical Cancer Research. 2020
    [Abstract] [Full Paper]
  • Cornacchia D#, Zhang C#, Zimmer B, Chung SY, Soliman MA, Fan Y, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley L, Cross J, Betel D, Studer L. Lipid deprivation induces naive-like features in human PSCs under primed-state activating growth factor conditions. Cell Stem Cell. 2019.
    [Abstract] [Full Paper]
  • Zhang C, Thakkar PV, Powell SE, Sharma P, Vennelaganti S, Betel D, Shah MA. A Comparison of Homogenization versus Enzymatic Lysis for Microbiome Profiling in Clinical Endoscopic Biopsy Tissue Samples. Frontiers in Microbiology. 2019
    [Abstract] [Full Paper]
  • Xu R, Yallowitz A, Qin A, Shin DY, Dong H, Zhang C, Wu Z, Lalanil S, Li N, Liu Y, Poulos M, Wach A, Zhang B, Butler J, Shim JH, Glimcher LH, Greenblatt MB. Osteoblast production of the axon-guidance cue SLIT3 controls skeletal angiogenesis and bone formation. Nature Medicine. 2018
    [Abstract] [Full Paper]
  • Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 2017
    [Abstract] [Full Paper]

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